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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHRNA4
All Species:
8.48
Human Site:
S539
Identified Species:
20.74
UniProt:
P43681
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43681
NP_000735.1
627
69957
S539
T
C
K
K
E
P
S
S
V
S
P
S
A
T
V
Chimpanzee
Pan troglodytes
Q5IS77
627
69934
S539
T
C
K
K
E
P
S
S
V
S
P
S
A
T
V
Rhesus Macaque
Macaca mulatta
XP_001114265
659
73255
S571
T
C
G
K
E
P
P
S
V
S
P
S
A
T
L
Dog
Lupus familis
XP_543097
681
74998
E593
C
K
C
R
C
K
K
E
P
S
P
S
A
V
P
Cat
Felis silvestris
Mouse
Mus musculus
O70174
629
70286
P541
C
T
C
K
E
P
S
P
V
S
P
I
T
V
L
Rat
Rattus norvegicus
P09483
630
70174
P543
C
T
C
K
E
P
S
P
V
S
P
V
T
V
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506577
624
70583
A536
C
K
K
N
K
A
P
A
S
P
D
P
G
A
K
Chicken
Gallus gallus
P09482
622
70820
A534
C
K
C
R
K
G
E
A
A
G
T
P
T
Q
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001041528
627
71089
Q539
R
H
N
M
P
S
A
Q
I
F
S
P
S
S
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P09478
567
64001
V491
S
R
F
I
A
Q
H
V
K
N
K
D
K
F
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.4
89.9
79.1
N.A.
84.7
83.8
N.A.
74.8
74.3
N.A.
62.2
N.A.
37.3
N.A.
N.A.
N.A.
Protein Similarity:
100
98.8
91
82.2
N.A.
89
87.4
N.A.
81.8
81.9
N.A.
70.6
N.A.
52.7
N.A.
N.A.
N.A.
P-Site Identity:
100
100
80
26.6
N.A.
46.6
46.6
N.A.
6.6
0
N.A.
0
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
86.6
33.3
N.A.
53.3
53.3
N.A.
20
20
N.A.
26.6
N.A.
13.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
10
10
20
10
0
0
0
40
10
0
% A
% Cys:
50
30
40
0
10
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
10
10
0
0
10
% D
% Glu:
0
0
0
0
50
0
10
10
0
0
0
0
0
0
10
% E
% Phe:
0
0
10
0
0
0
0
0
0
10
0
0
0
10
0
% F
% Gly:
0
0
10
0
0
10
0
0
0
10
0
0
10
0
10
% G
% His:
0
10
0
0
0
0
10
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
10
0
0
0
0
10
0
0
10
0
0
0
% I
% Lys:
0
30
30
50
20
10
10
0
10
0
10
0
10
0
10
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
30
% L
% Met:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
10
0
0
0
0
0
10
0
0
0
0
0
% N
% Pro:
0
0
0
0
10
50
20
20
10
10
60
30
0
0
10
% P
% Gln:
0
0
0
0
0
10
0
10
0
0
0
0
0
10
0
% Q
% Arg:
10
10
0
20
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
10
0
0
0
0
10
40
30
10
60
10
40
10
10
0
% S
% Thr:
30
20
0
0
0
0
0
0
0
0
10
0
30
30
0
% T
% Val:
0
0
0
0
0
0
0
10
50
0
0
10
0
30
20
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _